7 days
Asunción, Encarnación and Ciudad del Este
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Day 1–3
Asunción
Start in the capital, home to around 462,241 people. Use these days to settle in and explore the city at a relaxed pace.
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Day 4–5
Encarnación
Move south to this city of roughly 106,842 residents, smaller and quieter than the capital, good for a slower couple of days.
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Day 6–7
Ciudad del Este
Finish in Paraguay's second-largest city with about 350,000 people, a busy border town with a very different feel from Asunción.